Journal Article

The global burden of sepsis: barriers and potential solutions

Angus, Derek C., Rudd, Kristina E., Bory, Sotharith, Kissoon, Niranjan, Mutahunga, Birungi, West, T. Eoin, Seymour, Christopher W., Limmathurotsakul, Direk

2018

Overview

Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Cost of Illness / Critical Care Medicine / Developing Countries - statistics & numerical data / Distribution / Emergency Medicine / Global Health - trends / Health aspects / Health resources / Health Resources - supply & distribution / Health Resources - trends / Humans / Intensive / Low-income countries / Medicine / Medicine & Public Health / Patient outcomes / Poverty / Prevention / Public health / Review / Sepsis / Sepsis - epidemiology / World health