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Causal relationships of gut microbiota and blood metabolites with ovarian cancer and endometrial cancer: a Mendelian randomization study
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Causal relationships of gut microbiota and blood metabolites with ovarian cancer and endometrial cancer: a Mendelian randomization study
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Journal Article
Causal relationships of gut microbiota and blood metabolites with ovarian cancer and endometrial cancer: a Mendelian randomization study
2025
Overview
Objectives
The study aimed to investigate the causal relationships of gut microbiota (GM), ovarian cancer (OC), endometrial cancer (EC), and potential metabolite mediators using Mendelian randomization (MR) analysis.
Methods
Bidirectional two-sample MR analysis and reverse MR analysis of GM on OC/EC were employed to determine the causal effects of GM on OC/EC and the mediating role of blood metabolites in the relationship between GM and OC/EC, with results validated through sensitivity analysis.
Results
We identified 6 pathogenic bacterial taxa associated with OC, including
Euryarchaeota
,
Escherichia-Shigella
,
FamilyXIIIAD3011group
,
Prevotella9
, and two unknown genera.
Christensenellaceae R.7group
,
Tyzzerella3
, and
Victivallaceae
were found to be protective against OC. The increase in EC risk was positively associated with
Erysipelotrichia
,
Erysipelotrichaceae
,
Erysipelotrichales
, and
FamilyXI
.
Dorea
,
RuminococcaceaeUCG014
, and
Turicibacter
exhibited a negative correlation with the EC risk. A total of 26 and 19 blood metabolites related to GM were identified, showing significant correlations with OC and EC, respectively. Cytosine was found to be an intermediate metabolite greatly associated with EC and
FamilyXI
. In reverse MR analysis, the
FamilyXIIIAD3011group
exhibited a significant bidirectional causal relationship with OC.
Conclusion
Our study revealed causal relationships of GM and intermediate metabolites with OC/EC, providing new avenues for understanding OC/EC and developing effective treatment strategies.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Blood
/ Cancer
/ Cytosine
/ Endometrial Neoplasms - blood
/ Endometrial Neoplasms - genetics
/ Endometrial Neoplasms - microbiology
/ Female
/ Genetics
/ Humans
/ Medicine
/ Mendelian Randomization Analysis
/ Microbiota (Symbiotic organisms)
/ Ovarian Neoplasms - etiology
/ Ovarian Neoplasms - genetics
/ Ovarian Neoplasms - microbiology
/ Ratios
