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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
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Journal Article
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
2007
Overview
Cancer immunoresistance and immune escape
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may play important roles in tumor progression and pose obstacles for immunotherapy. Expression of the immunosuppressive protein B7 homolog 1 (B7-H1), also known as programmed death ligand-1 (PD-L1), is increased in many pathological conditions, including cancer
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. Here we show that expression of the gene encoding B7-H1 increases post transcriptionally in human glioma after loss of phosphatase and tensin homolog (PTEN) and activation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. Tumor specimens from individuals with glioblastoma multiforme (GBM) had levels of B7-H1 protein that correlated with PTEN loss, and tumor-specific T cells lysed human glioma targets expressing wild-type PTEN more effectively than those expressing mutant PTEN. These data identify a previously unrecognized mechanism linking loss of the tumor suppressor PTEN with immunoresistance, mediated in part by B7-H1.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Antibodies, Monoclonal - pharmacology
/ Biomedical and Life Sciences
/ Cancer
/ Cell Survival - drug effects
/ Enzyme Activation - drug effects
/ Humans
/ letter
/ Mutation
/ Protein Kinases - metabolism
/ Proteins
/ Proto-Oncogene Proteins c-akt - antagonists & inhibitors
/ Proto-Oncogene Proteins c-akt - metabolism
/ PTEN Phosphohydrolase - genetics
/ PTEN Phosphohydrolase - metabolism
/ Reverse Transcriptase Polymerase Chain Reaction
/ Ribosomal Protein S6 Kinases - genetics
/ Ribosomal Protein S6 Kinases - metabolism
/ Signal Transduction - drug effects
/ TOR Serine-Threonine Kinases
/ Tumors
