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Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study
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Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study
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Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study
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Journal Article
Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study
2018
Overview
Background
Respiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, with less known about other immunocompromised patients.
Methods
Ten-year retrospective cohort study of immunocompromised patients presenting with RSV disease documented at University Hospitals of Lausanne and Geneva. Severe RSV-related outcomes referred to RSV documented respiratory conditions requiring hospital admission, presenting as lower respiratory tract infection (LRTI) or pneumonia. We used multivariable logistic regression to assess clinical and laboratory correlates of severe RSV disease.
Results
From 239 RSV-positive immunocompromised in and out-patients 175 were adults and 64 children of whom 111 (47.8%) presented with LRTI, which resulted in a 38% (89/239) admission rate to hospital. While immunocompromised children were more likely to be admitted to hospital compared to adults (75% vs 62.9%,
p
= 0.090), inpatients admitted to the intensive care unit (17/19) or those who died (11/11) were mainly adults. From multivariable analyses, adults with solid tumors (OR 5.2; 95% CI: 1.4–20.9
P = 0.015
) or those requiring chronic immunosuppressive treatments mainly for rheumatologic conditions (OR 4.1; 95% CI: 1.1–16.0;
P = 0.034
) were significantly more likely to be admitted to hospital compared to hematopoietic stem cell (HSCT) recipients. Bacterial co-infection was significantly and consistently associated with viral LRTI and pneumonia.
Conclusions
From our findings, RSV-related disease results in a significant burden among adults requiring chronic immunosuppressive treatments for rheumatological conditions and those with solid tumors. As such, systematic screening for respiratory viruses, should be extended to other immunocompromised populations than HSCT recipients.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Adult
/ Adults
/ Child
/ Children
/ Female
/ Humans
/ Infant
/ Male
/ Medicine
/ Respiratory Syncytial Virus Infections - diagnosis
/ Respiratory Syncytial Virus Infections - etiology
/ Respiratory Syncytial Virus Infections - therapy
/ Respiratory Tract Infections - therapy
