Asset Details
Do you wish to reserve the book?
Gold nanoparticle imaging and radiotherapy of brain tumors in mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Gold nanoparticle imaging and radiotherapy of brain tumors in mice
Do you wish to request the book?
Gold nanoparticle imaging and radiotherapy of brain tumors in mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Gold nanoparticle imaging and radiotherapy of brain tumors in mice
2013
Overview
To test intravenously injected gold nanoparticles for x-ray imaging and radiotherapy enhancement of large, imminently lethal, intracerebral malignant gliomas.
Gold nanoparticles approximately 11 nm in size were injected intravenously and brains imaged using microcomputed tomography. A total of 15 h after an intravenous dose of 4 g Au/kg was administered, brains were irradiated with 30 Gy 100 kVp x-rays.
Gold uptake gave a 19:1 tumor to normal brain ratio with 1.5% w/w gold in tumor, calculated to increase local radiation dose by approximately 300%. Mice receiving gold and radiation (30 Gy) demonstrated 50% long term (>1 year) tumor-free survival, whereas all mice receiving radiation only died.
Intravenously injected gold nanoparticles cross the blood-tumor barrier, but are largely blocked by the normal blood-brain barrier, enabling high-resolution computed tomography tumor imaging. Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. This approach holds promise to improve therapy of human brain tumors and other cancers.
Original submitted 14 February 2012; Revised submitted 16 September 2012; Published online 24 December 2012
Publisher
Future Medicine Ltd,Future Medicine
Subject
/ Biological and medical sciences
/ Blood-Brain Barrier - drug effects
/ Brain Neoplasms - diagnostic imaging
/ Brain Neoplasms - radiotherapy
/ cancer
/ Contrast media. Radiopharmaceuticals
/ glioma
/ Gliomas
/ Gold
/ Gold - administration & dosage
/ Humans
/ imaging
/ Metal Nanoparticles - administration & dosage
/ Metal Nanoparticles - adverse effects
/ Methods
/ Mice
/ Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
/ NANOSCIENCE AND NANOTECHNOLOGY
/ Pharmacology. Drug treatments
/ Tumors
/ Tumors of the nervous system. Phacomatoses
/ x-ray
