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Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case–control study

by Labeyrie, Marc-Antoine , Chousterman, Benjamin Glenn , Ben Hassen, Wagih , Caillard, Anaïs , Trinh-Duc, Antoine , Mebazaa, Alexandre

in Cardiomyopathy / Case-Control Studies / Cerebral ischemia / Cerebral vasospasm / Complications and side effects / Critical care / Critical Care Medicine / Delayed cerebral ischemia / Drug therapy / Emergency Medicine / Hemorrhage / Humans / Intensive / Ischemia / Levosimendan / Life Sciences / Medicine / Medicine & Public Health / Prevention / Research Letter / Risk factors / Simendan - therapeutic use / Subarachnoid hemorrhage / Subarachnoid Hemorrhage - complications / Treatment Outcome / Vasodilators / Vasospasm, Intracranial - epidemiology / Vasospasm, Intracranial - prevention & control / Veins & arteries

2021

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Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case–control study

by Labeyrie, Marc-Antoine , Chousterman, Benjamin Glenn , Ben Hassen, Wagih , Caillard, Anaïs , Trinh-Duc, Antoine , Mebazaa, Alexandre

2021

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Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case–control study

by Labeyrie, Marc-Antoine , Chousterman, Benjamin Glenn , Ben Hassen, Wagih , Caillard, Anaïs , Trinh-Duc, Antoine , Mebazaa, Alexandre

2021

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Journal Article

Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case–control study

Labeyrie, Marc-Antoine,

Chousterman, Benjamin Glenn,

Ben Hassen, Wagih,

Caillard, Anaïs,

Trinh-Duc, Antoine,

Mebazaa, Alexandre

2021

Overview

Matching was performed on age, World Federation of Neurosurgical Societies (WFNS) grade, Fischer grade, need for external ventricular derivation (EVD) and severity assessed by Simplified Acute Physiology Score II (SAPS II). Regarding evolution of vessels diameters, we observed a slight increase in the median cerebral arteries diameters between D0 and D5–7 (0.03 mm (IQR [− 0.01; 0.06])) in the Levo group, while cerebral arteries showed signs of vasospasm with a decreasing diameter in the control group (− 0.47 mm (IQR [− 0.51; − 0.24]) (p = 0.002; Fig. 1). Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Cardiomyopathy

/ Case-Control Studies

/ Cerebral ischemia

/ Cerebral vasospasm

/ Complications and side effects

/ Critical care

/ Critical Care Medicine