Asset Details
MbrlCatalogueTitleDetail
Do you wish to reserve the book?
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
by
Rosen, Bruce
, Greve, Douglas N.
, Hansen, Adam E.
, Feng, Ling
, Baare, William
, Fischl, Bruce
, Knudsen, Gitte M.
, Fisher, Patrick M.
, Svarer, Claus
in
Adult
/ Algorithms
/ Binding sites
/ Biological and medical sciences
/ Brain
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Cortex - metabolism
/ Computer Simulation
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Image Enhancement - methods
/ Kinetics
/ Male
/ Medical imaging
/ Metabolic Clearance Rate
/ Methods
/ Models, Biological
/ Neighborhoods
/ Noise
/ Piperidines - pharmacokinetics
/ Positron-Emission Tomography - methods
/ Radiopharmaceuticals - pharmacokinetics
/ Receptors, Serotonin, 5-HT4 - metabolism
/ Reproducibility of Results
/ Scanners
/ Sensitivity and Specificity
/ Studies
/ Tissue Distribution
/ Vertebrates: nervous system and sense organs
/ Young Adult
2014
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
You are currently in the queue to collect this book. You will be notified once it is your turn to collect the book.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
by
Rosen, Bruce
, Greve, Douglas N.
, Hansen, Adam E.
, Feng, Ling
, Baare, William
, Fischl, Bruce
, Knudsen, Gitte M.
, Fisher, Patrick M.
, Svarer, Claus
in
Adult
/ Algorithms
/ Binding sites
/ Biological and medical sciences
/ Brain
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Cortex - metabolism
/ Computer Simulation
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Image Enhancement - methods
/ Kinetics
/ Male
/ Medical imaging
/ Metabolic Clearance Rate
/ Methods
/ Models, Biological
/ Neighborhoods
/ Noise
/ Piperidines - pharmacokinetics
/ Positron-Emission Tomography - methods
/ Radiopharmaceuticals - pharmacokinetics
/ Receptors, Serotonin, 5-HT4 - metabolism
/ Reproducibility of Results
/ Scanners
/ Sensitivity and Specificity
/ Studies
/ Tissue Distribution
/ Vertebrates: nervous system and sense organs
/ Young Adult
2014
Oops! Something went wrong.
While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
by
Rosen, Bruce
, Greve, Douglas N.
, Hansen, Adam E.
, Feng, Ling
, Baare, William
, Fischl, Bruce
, Knudsen, Gitte M.
, Fisher, Patrick M.
, Svarer, Claus
in
Adult
/ Algorithms
/ Binding sites
/ Biological and medical sciences
/ Brain
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Cortex - metabolism
/ Computer Simulation
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Image Enhancement - methods
/ Kinetics
/ Male
/ Medical imaging
/ Metabolic Clearance Rate
/ Methods
/ Models, Biological
/ Neighborhoods
/ Noise
/ Piperidines - pharmacokinetics
/ Positron-Emission Tomography - methods
/ Radiopharmaceuticals - pharmacokinetics
/ Receptors, Serotonin, 5-HT4 - metabolism
/ Reproducibility of Results
/ Scanners
/ Sensitivity and Specificity
/ Studies
/ Tissue Distribution
/ Vertebrates: nervous system and sense organs
/ Young Adult
2014
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
Journal Article
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
2014
Request Book From Autostore
and Choose the Collection Method
Overview
Exploratory (i.e., voxelwise) spatial methods are commonly used in neuroimaging to identify areas that show an effect when a region-of-interest (ROI) analysis cannot be performed because no strong a priori anatomical hypothesis exists. However, noise at a single voxel is much higher than noise in a ROI making noise management critical to successful exploratory analysis. This work explores how preprocessing choices affect the bias and variability of voxelwise kinetic modeling analysis of brain positron emission tomography (PET) data. These choices include the use of volume- or cortical surface-based smoothing, level of smoothing, use of voxelwise partial volume correction (PVC), and PVC masking threshold. PVC was implemented using the Muller-Gartner method with the masking out of voxels with low gray matter (GM) partial volume fraction. Dynamic PET scans of an antagonist serotonin-4 receptor radioligand ([11C]SB207145) were collected on sixteen healthy subjects using a Siemens HRRT PET scanner. Kinetic modeling was used to compute maps of non-displaceable binding potential (BPND) after preprocessing. The results showed a complicated interaction between smoothing, PVC, and masking on BPND estimates. Volume-based smoothing resulted in large bias and intersubject variance because it smears signal across tissue types. In some cases, PVC with volume smoothing paradoxically caused the estimated BPND to be less than when no PVC was used at all. When applied in the absence of PVC, cortical surface-based smoothing resulted in dramatically less bias and the least variance of the methods tested for smoothing levels 5mm and higher. When used in combination with PVC, surface-based smoothing minimized the bias without significantly increasing the variance. Surface-based smoothing resulted in 2–4 times less intersubject variance than when volume smoothing was used. This translates into more than 4 times fewer subjects needed in a group analysis to achieve similarly powered statistical tests. Surface-based smoothing has less bias and variance because it respects cortical geometry by smoothing the PET data only along the cortical ribbon and so does not contaminate the GM signal with that of white matter and cerebrospinal fluid. The use of surface-based analysis in PET should result in substantial improvements in the reliability and detectability of effects in exploratory PET analysis, with or without PVC.
•This is a study of the effects of preprocessing on exploratory PET analysis.•Volumetric 3D smoothing of PET data exacerbates the partial volume effect.•Volumetric smoothing and partial volume correction combine to increase variability.•Cortical surface-based smoothing does not exacerbate the partial volume effect.•Surface-based kinetic analysis reduces intersubject variance by a factor of 4.
Publisher
Elsevier Inc,Elsevier,Elsevier Limited
Subject
/ Biological and medical sciences
/ Brain
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Cortex - metabolism
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Kinetics
/ Male
/ Methods
/ Noise
/ Piperidines - pharmacokinetics
/ Positron-Emission Tomography - methods
/ Radiopharmaceuticals - pharmacokinetics
/ Receptors, Serotonin, 5-HT4 - metabolism
/ Scanners
/ Studies
This website uses cookies to ensure you get the best experience on our website.