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Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

by Chin, Brian , Gingras, Anne-Claude , Giaever, Guri , Istel, Fabian , Tsui, Kyle , Whiteway, Malcolm , Boone, Charles , Mitra, Robi David , Cheung, Doris , Bahr, Sondra , Reynolds, Todd B. , Cox, Michael J. , Schwarzmüller, Tobias , Cowan, Leah E. , Fink, Gerald R. , Nislow, Corey , Ryan, Owen , Lin, Zhen-Yuan , Vizeacoumar, Frederick , Gifford, David K. , Sellam, Adnane , Mayhew, David , Costanzo, Michael , Andrews, Brenda , Baryshnikova, Anastasia , Tebbji, Faiza , Shapiro, Rebecca S. , Kurat, Christoph F. , Kuchler, Karl

in allele / Alleles / biofilm / Biofilms / Biofilms - growth & development / Biological and medical sciences / Biomedical research / Candida / Candida albicans / Candida albicans - cytology / Candida albicans - genetics / Candida albicans - growth & development / Cell growth / cell structure / Deletion / Diploidy / DNA Mutational Analysis / Forages / foraging / Fundamental and applied biological sciences. Psychology / fungus growth / Gene Deletion / gene expression / Gene Expression Regulation, Fungal / gene identification / Genes / genome / Genomes / Genotype & phenotype / green fluorescent protein / growth / Haploidy / Hyphae - genetics / Hyphae - growth & development / Immune system / Medical research / Microbiology / Morphology / Morphology, structure, chemical composition / Mycology / Nuclear Proteins - genetics / nutrient cycling / Nutrients / Pathogens / phenotype / Phenotypes / polyploidy / promoter region / protein binding / protein localization / Regulator genes / Regulators / Saccharomyces cerevisiae / Saccharomyces cerevisiae - cytology / Saccharomyces cerevisiae - genetics / Saccharomyces cerevisiae - growth & development / Saccharomyces cerevisiae Proteins - genetics / Saccharomycetales / signal transduction / tissues / Trans-Activators - genetics / transcription factor / transcription factor flo8 / transcription factor Mss11 / Transcription factors / Transcription Factors - genetics / transcription regulation / Transcription, Genetic / unclassified drug / Yeast / Yeasts

2012

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Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

2012

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2012

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Journal Article

Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

Chin, Brian,

Gingras, Anne-Claude,

Giaever, Guri,

Istel, Fabian,

Tsui, Kyle,

Whiteway, Malcolm,

Boone, Charles,

Mitra, Robi David,

Cheung, Doris,

Bahr, Sondra,

Reynolds, Todd B.,

Cox, Michael J.,

Schwarzmüller, Tobias,

Cowan, Leah E.,

Fink, Gerald R.,

Nislow, Corey,

Ryan, Owen,

Lin, Zhen-Yuan,

Vizeacoumar, Frederick,

Gifford, David K.,

Sellam, Adnane,

Mayhew, David,

Costanzo, Michael,

Andrews, Brenda,

Baryshnikova, Anastasia,

Tebbji, Faiza,

Shapiro, Rebecca S.,

Kurat, Christoph F.,

Kuchler, Karl

2012

Overview

The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic pathogen Candida albicans to invade human tissues and evade the immune system. We constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain, Σ1278b. We identified genes involved in morphologically distinct forms of filamentation: haploid invasive growth, biofilm formation, and diploid pseudohyphal growth. Unique genes appear to underlie each program, but we also found core genes with general roles in filamentous growth, including MFG1 (YDL233w), whose product binds two morphogenetic transcription factors, Flo8 and Mss11, and functions as a critical transcriptional regulator of filamentous growth in both S. cerevisiae and C. albicans.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

allele

/ Alleles

/ biofilm

/ Biofilms

/ Biofilms - growth & development

/ Biological and medical sciences

/ Biomedical research