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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

by Jiang, Pan-Pan , Gnirke, Andreas , Jalloh, Abdul Azziz , Moigboi, Alex , Wohl, Shirlee , Bochicchio, James , Massally, James L. B. , Birren, Bruce W. , Qu, James , Nekoui, Mahan , Gbakie, Michael , Young, Sarah , Gevao, Sahr M. , Robert, Willie , Yozwiak, Nathan L. , Koninga, James , Sabeti, Pardis C. , Yillah, Mohamed , Lander, Eric S. , Moses, Lina M. , Kamara, Fatima K. , Kovoma, Alice , Saffa, Sidiki , Khan, S. Humarr , Murphy, Cheryl , Malboeuf, Christine M. , Dudas, Gytis , Garry, Robert F. , Andersen, Kristian G. , Sealfon, Rachel S. G. , Coomber, Moinya Ruth , Gladden, Adrianne D. , Grant, Donald S. , Happi, Christian , Winnicki, Sarah , Momoh, Mambu , Yang, Xiao , Fonnie, Mbalu , Nusbaum, Chad , Mustapha, Ibrahim , Goba, Augustine , Tucker, Veronica , Matranga, Christian B. , Sellu, Josephine , Kanneh, Lansana , Schaffner, Stephen F. , Konuwa, Edwin , Kanneh, Franklyn , Gire, Stephen K. , Colubri, Andres , Rambaut, Andrew , Fullah, Mohamed , Park, Daniel J. , Chapman, Sinéad B. , Kargbo, Kandeh , Foday, Momoh , Scheiffelin, John S. , Jalloh, Simbirie

in animals / Base Sequence / Central Africa / Disease Outbreaks / Disease transmission / Ebola virus / Ebolavirus / Ebolavirus - genetics / Ebolavirus - isolation & purification / Epidemics / Epidemiological Monitoring / Epidemiology / Evolution / Genetic diversity / Genetic Variation / Genome, Viral - genetics / Genomics / Genomics - methods / Guinea / Hemorrhagic Fever, Ebola - epidemiology / Hemorrhagic Fever, Ebola - transmission / Hemorrhagic Fever, Ebola - virology / human population / Human populations / Humans / monitoring / Mortality / Mutation / Origins / Outbreaks / researchers / Sequence Analysis, DNA / Sierra Leone / Sierra Leone - epidemiology / Surveillance / Viral diseases / Viruses

2014

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2014

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2014

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Journal Article

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Jiang, Pan-Pan,

Gnirke, Andreas,

Jalloh, Abdul Azziz,

Moigboi, Alex,

Wohl, Shirlee,

Bochicchio, James,

Massally, James L. B.,

Birren, Bruce W.,

Qu, James,

Nekoui, Mahan,

Gbakie, Michael,

Young, Sarah,

Gevao, Sahr M.,

Robert, Willie,

Yozwiak, Nathan L.,

Koninga, James,

Sabeti, Pardis C.,

Yillah, Mohamed,

Lander, Eric S.,

Moses, Lina M.,

Kamara, Fatima K.,

Kovoma, Alice,

Saffa, Sidiki,

Khan, S. Humarr,

Murphy, Cheryl,

Malboeuf, Christine M.,

Dudas, Gytis,

Garry, Robert F.,

Andersen, Kristian G.,

Sealfon, Rachel S. G.,

Coomber, Moinya Ruth,

Gladden, Adrianne D.,

Grant, Donald S.,

Happi, Christian,

Winnicki, Sarah,

Momoh, Mambu,

Yang, Xiao,

Fonnie, Mbalu,

Nusbaum, Chad,

Mustapha, Ibrahim,

Goba, Augustine,

Tucker, Veronica,

Matranga, Christian B.,

Sellu, Josephine,

Kanneh, Lansana,

Schaffner, Stephen F.,

Konuwa, Edwin,

Kanneh, Franklyn,

Gire, Stephen K.,

Colubri, Andres,

Rambaut, Andrew,

Fullah, Mohamed,

Park, Daniel J.,

Chapman, Sinéad B.,

Kargbo, Kandeh,

Foday, Momoh,

Scheiffelin, John S.,

Jalloh, Simbirie

2014

Overview

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

/ Disease transmission

/ Ebola virus

/ Ebolavirus