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2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam
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2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam
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Journal Article
2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam
2014
Overview
Dioxin levels in the breast milk of mothers residing near a contaminated former airbase in Vietnam remain much higher than in unsprayed areas, suggesting high perinatal dioxin exposure for their infants. The present study investigated the association of perinatal dioxin exposure with autistic traits in 153 3-year-old children living in a contaminated area in Vietnam. The children were followed up from birth using the neurodevelopmental battery Bayley-III. The high-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed groups (⩾3.5 pg per g fat) showed significantly higher Autism Spectrum Rating Scale (ASRS) scores for both boys and girls than the mild-TCDD exposed groups, without differences in neurodevelopmental scores. In contrast, the high total dioxin-exposed group, indicated by polychlorinated dibenzo-p-dioxins/furans (PCDDs/Fs)—the toxic equivalents (TEQ) levels⩾17.9 pg-TEQ per g fat, had significantly lower neurodevelopmental scores than the mild-exposed group in boys, but there was no difference in the ASRS scores. The present study demonstrates a specific impact of perinatal TCDD on autistic traits in childhood, which is different from the neurotoxicity of total dioxins (PCDDs/Fs).
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Autism
/ Autistic Disorder - epidemiology
/ Babies
/ Benzofurans - adverse effects
/ Child Development - drug effects
/ Children
/ Dioxin
/ Dioxins
/ Dose-Response Relationship, Drug
/ Female
/ Food contamination & poisoning
/ Furans
/ Humans
/ Male
/ Medicine
/ Mothers
/ PCB
/ Polychlorinated Dibenzodioxins - adverse effects
/ Polychlorinated Dibenzodioxins - analysis
/ Psychiatric Status Rating Scales
/ TCDD
