Journal Article

Critically ill patients with diabetes and Middle East respiratory syndrome: a multi-center observational study

Abdulmomen, Ahmed, Sadat, Musharaf, Al-Omari, Awad, Sindi, Anees A., Maghrabi, Khalid, Al-Hameed, Fahad, Qushmaq, Ismael, Mandourah, Yasser, Ragab, Ahmed, Jose, Jesna, Solaiman, Othman, Alraddadi, Basem, Al Harthy, Abdulrahman, Bhattacharjee, Atanu, Vishwakarma, Gajendra K., Al-Raddadi, Rajaa, Al Mekhlafi, Ghaleb A., Al Qasim, Eman, Mady, Ahmed, Almotairi, Abdullah, Kharaba, Ayman, Al-Aithan, Abdulsalam M., Shalhoub, Sarah, Al-Dorzi, Hasan M., Arabi, Yaseen M., Al Khatib, Kasim

2021

Overview

Background Diabetes is a risk factor for infection with coronaviruses. This study describes the demographic, clinical data, and outcomes of critically ill patients with diabetes and Middle East Respiratory Syndrome (MERS). Methods This retrospective cohort study was conducted at 14 hospitals in Saudi Arabia (September 2012–January 2018). We compared the demographic characteristics, underlying medical conditions, presenting symptoms and signs, management and clinical course, and outcomes of critically ill patients with MERS who had diabetes compared to those with no diabetes. Multivariable logistic regression analysis was performed to determine if diabetes was an independent predictor of 90-day mortality. Results Of the 350 critically ill patients with MERS, 171 (48.9%) had diabetes. Patients with diabetes were more likely to be older, and have comorbid conditions, compared to patients with no diabetes. They were more likely to present with respiratory failure requiring intubation, vasopressors, and corticosteroids. The median time to clearance of MERS-CoV RNA was similar (23 days (Q1, Q3: 17, 36) in patients with diabetes and 21.0 days (Q1, Q3: 10, 33) in patients with no diabetes). Mortality at 90 days was higher in patients with diabetes (78.9% versus 54.7%, p  < 0.0001). Multivariable regression analysis showed that diabetes was an independent risk factor for 90-day mortality (odds ratio, 2.09; 95% confidence interval, 1.18–3.72). Conclusions Half of the critically ill patients with MERS have diabetes; which is associated with more severe disease. Diabetes is an independent predictor of mortality among critically patients with MERS.

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Acute respiratory distress syndrome / Adrenal Cortex Hormones / Adult / Age Factors / Aged / Bronchoalveolar Lavage Fluid - virology / Cohort Studies / Comorbidity / Complications and side effects / Coronavirus / Coronavirus Infections - complications / Coronavirus Infections - epidemiology / Coronavirus Infections - mortality / Critical Illness / Critically ill / Diabetes / Diabetes Complications - epidemiology / Diabetes Mellitus - epidemiology / Female / Humans / Infectious Diseases / Internal Medicine / Male / Medical Microbiology / Medicine / Medicine & Public Health / Middle Aged / Middle East respiratory syndrome / Middle East Respiratory Syndrome Coronavirus - genetics / Middle East Respiratory Syndrome Coronavirus - isolation & purification / Nasopharynx - virology / Parasitology / Patient outcomes / Research Article / Respiratory Insufficiency - etiology / Respiratory Insufficiency - mortality / Retrospective Studies / Risk Factors / Saudi Arabia - epidemiology / Sputum - virology / Statistics / Trachea - virology / Tropical Medicine / Viral diseases