Asset Details
Do you wish to reserve the book?
Light-induced engagement of microglia to focally remodel synapses in the adult brain
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Light-induced engagement of microglia to focally remodel synapses in the adult brain
Do you wish to request the book?
Light-induced engagement of microglia to focally remodel synapses in the adult brain
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Light-induced engagement of microglia to focally remodel synapses in the adult brain
2020
Overview
Microglia continuously monitor synapses, but active synaptic remodeling by microglia in mature healthy brains is rarely directly observed. We performed targeted photoablation of single synapses in mature transgenic mice expressing fluorescent labels in neurons and microglia. The photodamage focally increased the duration of microglia-neuron contacts, and dramatically exacerbated both the turnover of dendritic spines and presynaptic boutons as well as the generation of new filopodia originating from spine heads or boutons. The results of microglia depletion confirmed that elevated spine turnover and the generation of presynaptic filopodia are microglia-dependent processes.
Publisher
eLife Science Publications, Ltd,eLife Sciences Publications, Ltd,eLife Sciences Publications Ltd
Subject
/ bouton
/ Brain
/ Green Fluorescent Proteins - chemistry
/ Light
/ Luminescent Proteins - chemistry
/ Male
/ Mice
/ Microglia - radiation effects
/ Microscopy, Fluorescence, Multiphoton
/ Neuronal Plasticity - radiation effects
/ Neurons
/ Presynaptic Terminals - physiology
/ Presynaptic Terminals - radiation effects
/ Pseudopodia - radiation effects
/ spine
