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Requirement of bic/microRNA-155 for Normal Immune Function

by van Dongen, Stijn , Vigorito, Elena , Enright, Anton J , Vetrie, David , Grocock, Russell J , Bradley, Allan , Okkenhaug, Klaus , Dougan, Gordon , Turner, Martin , Warren, Madhuri V , Couttet, Philippe , Rodriguez, Antony , Soond, Dalya R , Clare, Simon , Miska, Eric A , Das, Partha P

in 3' Untranslated Regions / Animals / B lymphocytes / B-Lymphocytes - immunology / Biological and medical sciences / CD4-positive T-lymphocytes / chemokines / Cultured cells / Cytokines / Cytokines - biosynthesis / dendritic cells / Dendritic Cells - immunology / Fundamental and applied biological sciences. Psychology / Fundamental immunology / Gene expression / Gene Expression Regulation / Gene Targeting / Genes / Genetics of the immune response / Genomics / Homeostasis / Immune response / Immune system / Immune System - physiology / Immunobiology / Immunoglobulin G - biosynthesis / Immunology / Lung - pathology / Lung Diseases - immunology / Lung Diseases - pathology / Lungs / Lymphocyte Activation / Lymphocytes / Mammals / Mice / MicroRNA / MicroRNAs - genetics / MicroRNAs - physiology / Oligonucleotide Array Sequence Analysis / Phenotypes / Proto-Oncogene Proteins c-maf - genetics / Proto-Oncogene Proteins c-maf - physiology / Ribonucleic acid / RNA / Rodents / Salmonella Infections, Animal - immunology / T lymphocytes / T-Lymphocytes - immunology / Th1 Cells - immunology / Th2 Cells - immunology / transcription (genetics) / transcription factors / transcriptomics / Untranslated regions / Vaccination

2007

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Requirement of bic/microRNA-155 for Normal Immune Function

2007

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2007

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Journal Article

Requirement of bic/microRNA-155 for Normal Immune Function

van Dongen, Stijn,

Vigorito, Elena,

Enright, Anton J,

Vetrie, David,

Grocock, Russell J,

Bradley, Allan,

Okkenhaug, Klaus,

Dougan, Gordon,

Turner, Martin,

Warren, Madhuri V,

Couttet, Philippe,

Rodriguez, Antony,

Soond, Dalya R,

Clare, Simon,

Miska, Eric A,

Das, Partha P

2007

Overview

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4⁺ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

3' Untranslated Regions

/ Animals

/ B lymphocytes

/ B-Lymphocytes - immunology

/ Biological and medical sciences

/ CD4-positive T-lymphocytes

/ chemokines