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Molecular Identification and In Vitro Antifungal Susceptibility of Aspergillus Isolates Recovered from Otomycosis Patients in Western China
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Molecular Identification and In Vitro Antifungal Susceptibility of Aspergillus Isolates Recovered from Otomycosis Patients in Western China
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Journal Article
Molecular Identification and In Vitro Antifungal Susceptibility of Aspergillus Isolates Recovered from Otomycosis Patients in Western China
2020
Overview
Aspergillus
species are the most common causative agents involved in otomycosis. In this study, 45
Aspergillus
isolates were obtained from patients with otomycosis in western China during 2013–2016. The aim of this study is to identify the
Aspergillus
isolates to the species level by using
β-tubulin
gene sequencing and to evaluate their in vitro susceptibility to nine antifungal drugs: amphotericin B, itraconazole, voriconazole, posaconazole, ravuconazole, isavuconazole, caspofungin, micafungin and anidulafungin according to CLSI M38-A2. Our results indicate that
A. tubingensis
(18/45) is the predominant
Aspergillus
species causing ear infections in western China, which is three times more than its sibling species
A. niger
(6/45) and
A. welwitschiae
(2/45). Other detected species were
A. fumigatus
(
n
= 8),
A. terreus
(
n
= 7) and
A. flavus
(
n
= 4). Antifungal susceptibility data indicate that triazoles and echinocandins are active against the most
Aspergillus
isolates. There are no significant differences in the susceptibility among
A. niger, A. tubingensis
and
A. welwitschiae
to each of the antifungals tested. One azole-resistant
A. fumigatus
isolate with a TR34/L98H mutation in the
CYP51A
gene and one posaconazole-resistant
A. terreus
isolate presented among the studied isolates. In conclusion,
A. tubingensis
is the most prevalent
Aspergillus
species causing otomycosis in western China. Posaconazole and echinocandins are potential drugs for treatment of otomycosis due to
Aspergillus
; however, in vivo efficacy remains to be determined.
Publisher
Springer Netherlands,Springer,Springer Nature B.V
Subject
