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Lessons from ecology for understanding the heterogeneity of bipolar disorder
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Journal Article
Lessons from ecology for understanding the heterogeneity of bipolar disorder
2022
Overview
Bipolar disorder (BD) is a lifelong neuropsychiatric disorder that exerts a substantial personal and public health toll, an elevated lifetime risk of suicide, and a remarkable degree of heterogeneity or diversity. Existing studies of heterogeneity in BD tend to focus on variability or clustering along a limited number of features or domains. However, identifying heterogeneity across a limited number of features does not necessarily help us characterize the overall heterogeneity of BD across levels of analysis. Until recently, it was not clear how heterogeneity should best be measured or conceptualized, thereby limiting our ability to understand the diversity of BD in a holistic sense. In addition to these recent advancements in heterogeneity measurement, understanding the diversity of BD requires us to develop research strategies and methods specific to this purpose. Here, Nunes et al argue that understanding the diversity of BD involves characterizing its nature, causes and consequences.
