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Regulation of Alternative Splicing by Histone Modifications
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Journal Article
Regulation of Alternative Splicing by Histone Modifications
2010
Overview
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Epithelial Cells - metabolism
/ Exons
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Histone-Lysine N-Methyltransferase - genetics
/ Histone-Lysine N-Methyltransferase - metabolism
/ Histones
/ Humans
/ Male
/ Mesenchymal Stem Cells - metabolism
/ Molecular and cellular biology
/ Polypyrimidine Tract-Binding Protein - metabolism
/ Proteins
/ reading
/ Receptor, Fibroblast Growth Factor, Type 2 - genetics
/ RNA
/ Splicing
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Transcription. Transcription factor. Splicing. Rna processing
