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Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus
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Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus
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Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus
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Journal Article
Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus
2025
Overview
Background
Human norovirus (HNV) is the predominant pathogen causing outbreaks of acute gastroenteritis globally. Despite significant efforts to combat norovirus infections, there is currently no FDA approved vaccine or antiviral drug available. Consequently, the development of effective antiviral agents is of critical importance.
Methods and results
In this study, a series of 41 5-cyano-2-thiacetyl aromatic pyrimidinone compounds were designed and synthesized. A cell viability-based screening for anti-murine norovirus (MNV) compounds was conducted, revealing that compound 29 (hereafter used as Co-29) exhibited antiviral activity against MNV. Co-29 demonstrated effective inhibition of MNV
CW3
RNA replication, exhibiting an EC
50
of 58.22 μM. An RdRp enzyme activity assay indicated that Co-29 directly inhibits RdRp activity to both MNV and HNV. Molecular docking studies suggested that Co-29 interacts with the palm region of RdRp via hydrogen bonding with specific residues, which are conserved in RdRps across MNV and HNV norovirus variants.
Conclusions
In conclusion, our study suggests that the newly synthesized Co-29 may serve as a potential antiviral candidate or lead compound for future studies.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Antiviral Agents - chemical synthesis
/ Antiviral Agents - chemistry
/ Antiviral Agents - pharmacology
/ Biomedical and Life Sciences
/ Cell Survival - drug effects
/ Co-29
/ Enzymes
/ Genomes
/ Humans
/ hydrogen
/ Identification and classification
/ Mice
/ Molecular Docking Simulation
/ Pyrimidinones - chemical synthesis
/ Pyrimidinones - pharmacology
/ RdRp
/ RNA-Dependent RNA Polymerase - antagonists & inhibitors
/ vaccines
/ Virology
/ Virus Replication - drug effects
/ Viruses
