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The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
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The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
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Journal Article
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
2016
Overview
Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals. The majority of the MS-associated gene variants are located in genetic regions with importance for T-cell differentiation. Vitamin D is a potent immunomodulator, and vitamin D deficiency has been suggested to be associated with increased MS disease susceptibility and activity. In CD4+ T cells, we have analyzed
in vitro
vitamin D responsiveness of genes that contain an MS-associated single-nucleotide polymorphism (SNP) and with one or more vitamin D response elements in their regulatory regions. We identify
IL2RA
and
TAGAP
as novel vitamin D target genes. The vitamin D response is observed in samples from both MS patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38
/ 38/77
/ 45
/ Adult
/ Analysis
/ Biomedical and Life Sciences
/ CD4-Positive T-Lymphocytes - drug effects
/ CD4-Positive T-Lymphocytes - metabolism
/ CD4-Positive T-Lymphocytes - pathology
/ Complications and side effects
/ Female
/ Genetic Predisposition to Disease
/ GTPase-Activating Proteins - agonists
/ GTPase-Activating Proteins - blood
/ GTPase-Activating Proteins - genetics
/ Humans
/ Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors
/ Interleukin-2 Receptor alpha Subunit - blood
/ Interleukin-2 Receptor alpha Subunit - genetics
/ Male
/ Multiple Sclerosis - genetics
/ Multiple Sclerosis - pathology
/ Original
/ Polymorphism, Single Nucleotide
/ Receptors, Calcitriol - blood
/ Receptors, Calcitriol - genetics
