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Four novel genes associated with longevity found in Cane corso purebred dogs
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Four novel genes associated with longevity found in Cane corso purebred dogs
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Journal Article
Four novel genes associated with longevity found in Cane corso purebred dogs
2022
Overview
Background
Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity.
Results
SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes,
TDRP
,
MC2R
,
FBXO25
and
FBXL21
. In
FBXL21
, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs.
Conclusions
Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes
TDRP
,
MC2R
,
FBXO25
and
FBXL21
are associated with longevity in Cane corso dogs.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
