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Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
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Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
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Journal Article
Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
2019
Overview
Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased responses. These results imply that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealing heterogeneity in input dominance across cells.Previous studies have suggested that cortical input can drive spatially tuned responses in hippocampal CA1 neurons. Here we use acute inactivation to demonstrate that CA3 is the predominant driver of CA1 responses under normal conditions.
Publisher
Nature Publishing Group
Subject
