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Bone marrow mesenchymal stem cell therapy in ischemic stroke： mechanisms of action and treatment optimization strategies
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Bone marrow mesenchymal stem cell therapy in ischemic stroke： mechanisms of action and treatment optimization strategies
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Journal Article
Bone marrow mesenchymal stem cell therapy in ischemic stroke： mechanisms of action and treatment optimization strategies
2016
Overview
Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction,angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action,and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke.We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.
Publisher
Wolters Kluwer - Medknow Publications,Medknow Publications & Media Pvt. Ltd,Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China%School of Pharmacy, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China%Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
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