Journal Article

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Total Knee Arthroplasty

Borris, Lars C, Rosencher, Nadia, Lassen, Michael R, Lieberman, Jay R, Bandel, Tiemo J, Turpie, Alexander G.G, Misselwitz, Frank, Ageno, Walter

2008

Overview

This trial compared rivaroxaban with enoxaparin for thromboprophylaxis after total knee replacement. Rivaroxaban was superior to enoxaparin in the prevention of venous thrombosis, and the two drugs had similar safety profiles. For thromboprophylaxis after total knee replacement, rivaroxaban was superior to enoxaparin in the prevention of venous thrombosis, and the two drugs had similar safety profiles. Venous thromboembolism is a major, potentially fatal complication after major orthopedic surgery such as total knee arthroplasty. 1 Anticoagulants that are currently used for thromboprophylaxis require parenteral administration or have unpredictable pharmacodynamic properties that require monitoring. 2 Several anticoagulants currently in development target individual coagulation factors, including thrombin and activated factor X (factor Xa). The efficacy of the parenterally administered indirect factor Xa inhibitor fondaparinux for thromboprophylaxis encouraged the development of direct factor Xa inhibitors. 3 Rivaroxaban (Xarelto, Bayer HealthCare) is an orally active direct factor Xa inhibitor. 4 Phase 2 studies showed that rivaroxaban was potentially safe and effective for thromboprophylaxis after major . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult / Aged / Aged, 80 and over / Anticoagulants - adverse effects / Anticoagulants - therapeutic use / Arthroplasty, Replacement, Knee / Biological and medical sciences / Blood clots / Cardiology and Cardiovascular Disease / Clinical Medicine / Clinical outcomes / Clinical trials / Comparative studies / Double-Blind Method / Drug therapy / Enoxaparin - adverse effects / Enoxaparin - therapeutic use / Factor Xa Inhibitors / Female / General aspects / Humans / Joint surgery / Kardiologi och kardiovaskulära sjukdomar / Kirurgi / Klinisk medicin / Knee / Male / Medical and Health Sciences / Medical sciences / Medicin och hälsovetenskap / Middle Aged / Morpholines - adverse effects / Morpholines - therapeutic use / Orthopedic surgery / Prevention and actions / Public health. Hygiene / Public health. Hygiene-occupational medicine / Pulmonary Embolism - epidemiology / Pulmonary Embolism - prevention & control / Rivaroxaban / Surgery / Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases / Thiophenes - adverse effects / Thiophenes - therapeutic use / Venous Thromboembolism - epidemiology / Venous Thromboembolism - mortality / Venous Thromboembolism - prevention & control / Venous Thrombosis - epidemiology / Venous Thrombosis - prevention & control