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Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China
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Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China
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Journal Article
Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China
2025
Overview
Background
The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance.
Methods
In 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed.
Result
The strain had reversion mutations at the known attenuation site 5’ non-coding region and recombined with Sabin1, Phylogenetic analysis of the
VP1
coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally.
Conclusion
It is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Biomedical and Life Sciences
/ China
/ Feces
/ Genomes
/ Hand, Foot and Mouth Disease - virology
/ Hand, foot, and mouth disease
/ Humans
/ mouth
/ patients
/ Poliovirus - isolation & purification
/ Poliovirus Vaccine, Oral - adverse effects
/ Poliovirus Vaccine, Oral - genetics
/ Sewage
/ Vaccines
/ Virology
