Journal Article

Practice guidelines for the management of Helicobacter pylori infection: The Saudi H. pylori Working Group recommendations

Almadi, Majid, Azzam, Nahla, Somily, Ali, Alshahrani, Abdulaziz, Alsohaibani, Fahad, Peedikayil, Musthafa, Alsulaiman, Raed

2023

Overview

Abstract The eradication rates for Helicobacter pylori globally are decreasing with a dramatic increase in the prevalence of antibiotic resistant bacteria all over the world, including Saudi Arabia. There is no current consensus on the management of H. pylori in Saudi Arabia. The Saudi Gastroenterology Association developed these practice guidelines after reviewing the local and regional studies on the management of H. pylori. The aim was to establish recommendations to guide healthcare providers in managing H. pylori in Saudi Arabia. Experts in the areas of H. pylori management and microbiology were invited to write these guidelines. A literature search was performed, and all authors participated in writing and reviewing the guidelines. In addition, international guidelines and consensus reports were reviewed to bridge the gap in knowledge when local and regional data were unavailable. There is limited local data on treatment of H. pylori. The rate of clarithromycin and metronidazole resistance is high; therefore, standard triple therapy for 10-14 days is no longer recommended in the treatment of H. pylori unless antimicrobial susceptibility testing was performed. Based on the available data, bismuth quadruple therapy for 10-14 days is considered the best first-line and second-line therapy. Culture and antimicrobial susceptibility testing should be considered following two treatment failures. These recommendations are intended to provide the most relevant evidence-based guidelines for the management of H. pylori infection in Saudi Arabia. The working group recommends further studies to explore more therapeutic options to eradicate H. pylori.

• Publisher: Wolters Kluwer - Medknow,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Wolters Kluwer Medknow Publications
• Subject: Amoxicillin / Anti-Bacterial Agents - therapeutic use / Antimicrobial agents / Antiulcer drugs / bismuth / Bismuth - therapeutic use / clarithromycin / Clinical Practice Guidelines / Disease control / Drug resistance / Drug resistance in microorganisms / Drug Therapy, Combination / Gastrointestinal diseases / Health aspects / Health care industry / Helicobacter infections / Helicobacter Infections - drug therapy / Helicobacter Infections - epidemiology / Helicobacter pylori / Helicobacter pylori - drug effects / Humans / Metronidazole / Proton Pump Inhibitors / quadruple therapy / Rifabutin / saudi arabia / Saudi Arabia - epidemiology / sequential / Tetracycline / Tetracyclines / triple therapy / Working groups