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Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia
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Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia
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Journal Article
Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia
2008
Overview
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and vomiting with subsequent deterioration and multiple hemorrhagic signs. A non-cytopathic virus was isolated from two of the patient serum samples, and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses known to be associated with HF (Guanarito, Machupo, and Sabiá). RT-PCR analysis and subsequent analysis of the complete virus S and L RNA segment sequences identified the virus as a member of the New World Clade B arenaviruses, which includes all the pathogenic South American arenaviruses. The virus was shown to be most closely related to Sabiá virus, but with 26% and 30% nucleotide difference in the S and L segments, and 26%, 28%, 15% and 22% amino acid differences for the L, Z, N, and GP proteins, respectively, indicating the virus represents a newly discovered arenavirus, for which we propose the name Chapare virus. In conclusion, two different arenaviruses, Machupo and Chapare, can be associated with severe HF cases in Bolivia.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Arenaviruses, New World - classification
/ Arenaviruses, New World - genetics
/ Arenaviruses, New World - isolation & purification
/ Bolivia
/ Evolutionary Biology/Evolutionary and Comparative Genetics
/ Fever
/ Genetics and Genomics/Microbial Evolution and Genomics
/ Genomes
/ Hemorrhagic Fever, American - diagnosis
/ Hemorrhagic Fever, American - virology
/ Humans
/ Infectious Diseases/Tropical and Travel-Associated Diseases
/ Male
/ Microbiology/Microbial Evolution and Genomics
/ Molecular Biology/Molecular Evolution
/ Public Health and Epidemiology/Global Health
/ Public Health and Epidemiology/Infectious Diseases
/ Rodents
/ Sequence Homology, Amino Acid
/ Virology/Emerging Viral Diseases
/ Virology/Virus Evolution and Symbiosis
/ Viruses
