Journal Article

Consecutive sessions of transcranial direct current stimulation do not remediate visual hallucinations in Lewy body dementia: a randomised controlled trial

Elder, Greg J., Firbank, Michael J., Taylor, John-Paul, Colloby, Sean J., McKeith, Ian G.

2019

Overview

Background Complex visual hallucinations are common in Lewy body dementia (LBD) and can cause significant patient and caregiver distress. Current treatments are primarily pharmacological in nature and have limited efficacy and associated side effects. The objective of this study was to assess the effects of consecutive sessions of transcranial direct current stimulation (tDCS) on visual hallucination frequency and severity in LBD, at short-term and long-term follow-up stages. Methods The study was a randomised, double-blind, placebo-controlled trial involving 40 participants with LBD (M age  = 75.52 years, SD age  = 8.69 years) which was conducted at a single site between November 2013 and December 2017. Participants received two consecutive 20-min sessions of active (0.048 mA/cm 2 ) or placebo tDCS, separated by a 30-min break, over 5 consecutive days. The anodal electrode was applied to the right parietal cortex (P4) and the cathodal electrode was applied to the occipital cortex (O z ). The primary outcome measure was the Neuropsychiatric Inventory (NPI) hallucinations subscale, as completed by a caregiver/informant at baseline and day 5 (short-term) follow-up, and month 1 and month 3 (long-term) follow-up. Secondary outcome measures included visual cortical excitability, as measured using transcranial magnetic stimulation, computerised attentional and visuoperceptual tasks, and measures of global cognition and cognitive fluctuations. Results Complete study data were obtained from 36 participants. There was an overall improvement in visual hallucinations (NPI) for both groups at day 5 relative to baseline, with a medium-to-large effect size; however, compared to placebo, active tDCS did not result in any improvements in visual hallucinations (NPI) at day 5 relative to baseline, or at month 1 or month 3 follow-up time points. Additionally, comparisons of secondary outcome measures showed that active tDCS did not result in any improvements on any measure (visual cortical excitability, attentional and visuoperceptual tasks or cognitive measures) at any time point. Conclusions Repeated consecutive sessions of parietal anodal tDCS, and occipital cathodal tDCS, do not improve visual hallucinations or visuoperceptual function, or alter visual cortical excitability in LBD. Trial registration ISRCTN, ISRCTN40214749 . Registered on 25 October 2013.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Aged / Aged, 80 and over / Alzheimer's disease / Analysis / Biomedical and Life Sciences / Biomedicine / Brain / Brain research / Care and treatment / Caregivers / Clinical trials / Cognition & reasoning / Complications and side effects / Dementia / Dementia with Lewy bodies / Double-Blind Method / Evidence-based medicine / Female / Follow-Up Studies / Geriatric Psychiatry / Geriatrics/Gerontology / Hallucinations / Hallucinations - diagnosis / Hallucinations - psychology / Hallucinations - therapy / Humans / Lewy body dementia / Lewy body disease / Lewy Body Disease - diagnosis / Lewy Body Disease - psychology / Lewy Body Disease - therapy / Male / Neurology / Neurosciences / Parkinson's disease / Parkinson’s disease dementia / Patient outcomes / Patients / Photic Stimulation - methods / Prospective Studies / Psychotropic drugs / Reaction Time - physiology / Transcranial direct current stimulation / Transcranial Direct Current Stimulation - methods / Transcranial Direct Current Stimulation - trends / Transcranial magnetic stimulation / Transcutaneous electrical nerve stimulation / Visual hallucinations