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Few and Far Between: How HIV May Be Evading Antibody Avidity
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Journal Article
Few and Far Between: How HIV May Be Evading Antibody Avidity
2010
Overview
[...]the extent and mode of protection are still under debate [2]. [...]a vaccine that effectively stimulates complete protective immunity by the cellular branch (cytotoxic T lymphocytes) and/or the humoral branch (antibodies) of the immune system has yet to emerge. An alternative approach, as others have proposed [56], [57], may lie in eliciting anti-carbohydrate antibodies, as the high density of glycans on each gp120 monomer should enable efficient bivalent binding to individual envelope spikes. [...]new immunogens designed to elicit antibodies capable of intra-spike cross-linking--either carbohydrate epitopes within or between spike monomers, or protein epitopes between spike monomers--may prove critical to the induction of a broadly cross-reactive neutralizing antibody response.
Publisher
Public Library of Science,Public Library of Science (PLoS)
