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Defensins and Viral Infection: Dispelling Common Misconceptions
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Defensins and Viral Infection: Dispelling Common Misconceptions
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Journal Article
Defensins and Viral Infection: Dispelling Common Misconceptions
2014
Overview
[...]produced HD5 from Neisseria gonorrhoeae-infected cells also enhances HIV infection, suggesting that it is likely to occur under physiological conditions in vivo [15]. Misconception: Defensin In Vitro Activity Predicts Their Role In Vivo In addition to direct effects on viral infection, defensins also target cells and are immunomodulatory [6], [17], [18]. [...]even defensins that are not directly antiviral could influence the activation and function of immune cells recruited to a site of viral infection, thereby impacting viral pathogenesis in vivo.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Complications and side effects
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Lipids
/ Pearls
/ Peptides
/ Studies
/ Viruses
