Journal Article

Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

Saito, Kazuyoshi, Sugihara, Takahiko, Harigai, Masayoshi, Hagiyama, Hiroyuki, Nonomura, Yoshinori, Hirata, Shinya, Tomita, Makoto, Miyasaka, Nobuyuki, Yokogawa, Naoto, Kihara, Mari, Kondo, Masahiro, Kohsaka, Hitoshi, Nagasaka, Kenji, Odani, Toshio, Takenaka, Kenchi, Suzuki, Fumihito, Soejima, Makoto, Utsunomiya, Masako, Hirano, Fumio, Koike, Ryuji, Matsui, Kazuo, Sakai, Ryoko, Dobashi, Hiroaki, Yamazaki, Hayato, Nanki, Toshihiro, Yokoyama, Waka

2017

Overview

Background Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystis pneumonia (PJP) in immunosuppressed patients with systemic rheumatic diseases, but is sometimes discontinued due to adverse events (AEs). The objective of this non-blinded, randomized, 52-week non-inferiority trial was to quest an effective chemoprophylaxis regimen for PJP with a low drug discontinuation rate. Results at week 24 were reported. Methods Adult patients with systemic rheumatic diseases who started prednisolone ≥0.6 mg/kg/day were randomized into three dosage groups: a single-strength group (SS, SMX/TMP of 400/80 mg daily), half-strength group (HS, 200/40 mg daily), and escalation group (ES, started with 40/8 mg daily, increasing incrementally to 200/40 mg daily). The primary endpoint was non-incidence rates (non-IR) of PJP at week 24. Results Of 183 patients randomly allocated at a 1:1:1 ratio into the three groups, 58 patients in SS, 59 in HS, and 55 in ES started SMX/TMP. A total of 172 patients were included in the analysis. No cases of PJP were reported up to week 24. Estimated non-IR of PJP in patients who received daily SMX/TMP of 200/40 mg, either starting at this dose or increasing incrementally, was 96.8–100% using the exact confidence interval as a post-hoc analysis. The overall discontinuation rate was significantly lower with HS compared to SS ( p  = 0.007). The discontinuation rates due to AEs were significantly lower with HS ( p  = 0.006) and ES ( p  = 0.004) compared to SS. The IR of AEs requiring reduction in the dose of SMX/TMP ( p  = 0.009) and AEs of special interest ( p  = 0.003) were different among the three groups with significantly higher IR in SS compared to HS and ES. Conclusions Although there were no PJP cases, the combined group of HS and ES had an excellent estimated non-IR of PJP and both were superior in safety to SS. From the perspective of feasibility and drug discontinuation rates, the daily half-strength regimen was suggested to be optimal for prophylaxis of PJP in patients with systemic rheumatic diseases. Trial registration The University Hospital Medical Information Network Clinical Trials Registry number is UMIN000007727 , registered 10 April 2012.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V
• Subject: Adult / Aged / Anti-Bacterial Agents - administration & dosage / Anti-Bacterial Agents - adverse effects / Arthritis / Care and treatment / Chemoprevention / Dosage and administration / Dose-Response Relationship, Drug / Female / Humans / Immunocompromised Host / Male / Medicine / Medicine & Public Health / Middle Aged / Orthopedics / Pneumocystis carinii pneumonia / Pneumonia, Pneumocystis - immunology / Pneumonia, Pneumocystis - prevention & control / Research Article / Rheumatic diseases / Rheumatic Diseases - immunology / Rheumatology / Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage / Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects / Trimethoprim-sulfamethoxazole (Drug combination)