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Translation and functional roles of circular RNAs in human cancer
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Translation and functional roles of circular RNAs in human cancer
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Journal Article
Translation and functional roles of circular RNAs in human cancer
2020
Overview
Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification and potential functions. CircRNAs play important roles in various biological functions as microRNA sponges, transcriptional regulators and combining with RNA binding proteins. Recent studies indicated that some cytoplasmic circRNAs can be effectively translated into detectable peptides, which enlightened us on the importance of circRNAs in cellular physiology function. Internal Ribosome Entry site (IRES)- and N
6
-methyladenosines (m
6
A)-mediated cap-independent translation initiation have been suggested to be potential mechanism for circRNA translation. To date, several translated circRNAs have been uncovered to play pivotal roles in human cancers. In this review, we introduced the properties and functions of circRNAs, and characterized the possible mechanism of translation initiation and complexity of the translation ability of circRNAs. We summarized the emerging functions of circRNA-encoded proteins in human cancer. The works on circRNA translation will open a hidden human proteome, and enhance us to understand the importance of circRNAs in human cancer, which has been poorly explored so far.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Animals
/ Biomarkers, Tumor - genetics
/ Biomedical and Life Sciences
/ Cancer
/ Function
/ Gene Expression Regulation, Neoplastic
/ Genomes
/ Humans
/ Internal ribosome entry site
/ MicroRNA
/ miRNA
/ Non-coding RNAs and RNA modifiers in cancer progression and cancer cells resistance to therapies
/ Oncology
/ Peptides
/ Proteins
/ Review
/ RNA
/ RNA-Binding Proteins - genetics
