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Spinal genesis of Mayer waves
Journal Article

Spinal genesis of Mayer waves

2020
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Overview
Variability in cardiovascular spectra was first described by Stephan Hales in 1733. Traube and Hering initially noted respirophasic variation of the arterial pressure waveform in 1865 and Sigmund Mayer noted a lower frequency oscillation of the same in anesthetized rabbits in 1876. Very low frequency oscillations were noted by Barcroft and Nisimaru in 1932, likely representing vasogenic autorhythmicity. While the origins of Traube Hering and very low frequency oscillatory variability in cardiovascular spectra are well described, genesis mechanisms and functional significance of Mayer waves remain in controversy. Various theories have posited baroreflex and central supraspinal mechanisms for genesis of Mayer waves. Several studies have demonstrated the persistence of Mayer waves following high cervical transection, indicating a spinal capacity for genesis of these oscillations. We suggest a general tendency for central sympathetic neurons to oscillate at the Mayer wave frequency, the presence of multiple Mayer wave oscillators throughout the brainstem and spinal cord, and possible contemporaneous genesis by baroreflex and vasomotor mechanisms.
Publisher
Wolters Kluwer - Medknow,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,United States Environmental Protection Agency, Arlington, VA, USA,Department of Toxicology, Purdue University, West Lafayette, IN, USA%Department of Neurological Surgery, Houston Methodist Hospital, Houston, TX, USA,Department of Cardiothoracic Surgery, El Gomhoureya General Hospital, Alexandria, Egypt,Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA%Department of Medicine, Inova Alexandria Hospital, Alexandria, VA, USA,Wolters Kluwer Medknow Publications