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Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
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Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
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Journal Article
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
2018
Overview
To examine the transmission dynamics of
Mycobacterium tuberculosis
(Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data identify an underlying burden of disease caused by the endemic Mtb lineage 1 associated with the activation of long-term latent infection, and a threefold higher burden associated with the more recently introduced Beijing lineage and lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than the endemic lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify an alteration in the ESX-5 type VII-secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations.
Genomic analysis of
Mycobacterium tuberculosis
(Mtb) isolated from tuberculosis patients identifies the transmission dynamics of Mtb in Vietnam including frequent transmission of Beijing lineage and positive selection for EsxW Beijing variant.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 13/106
/ 38
/ 38/91
/ 45
/ 45/22
/ 45/23
/ 82
/ 82/80
/ 82/83
/ Animal Genetics and Genomics
/ Beijing
/ Biomedical and Life Sciences
/ Genomes
/ Genomics
/ Genotype
/ Humans
/ Males
/ Multiculturalism & pluralism
/ Mutation
/ Mycobacterium tuberculosis - genetics
/ Polymorphism, Single Nucleotide
/ Proteins
/ Vietnam
