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Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer
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Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer
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Journal Article
Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer
2021
Overview
Background
Diacylglycerol-acyltransferase 1 (
DGAT1
) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of
DGAT1
in cancer tissue indicated a poor outcome in cancer patients. However, the relationship between
DGAT1
and gastric cancer is still unclear. Thus, Transcriptomic analysis and in vitro experiments were performed to investigate the role of
DGAT1
in gastric cancer, as well as the potential therapy target in gastric cancer treatment.
Methods
We screened the public cancer datasets to identify the expression and function of
DGAT1
in gastric cancer and tumor infiltrating lymphocytes. Then we testified the
DGAT1
expression and function after sodium oleate treatment in AGS and MKN45 cell line. Finally, we analyzed ration of apoptosis, necrosis in gastric cancer cells by using flow cytometry after administration of
DGAT1
inhibitor.
Results
Our results showed a highly expression of
DGAT1
in gastric cancer tissues (
n
= 5,
p
= 0.0004), and tumor-infiltrating macrophages with elevated
DGAT1
expression is associated with poor overall survival in gastric cancer patients. In addition, gastric cell lines AGS (
n
= 3,
p
< 0.05) and MKN45 (
n
= 3,
p
< 0.01) expressed higher level of
DGAT1
than human gastric mucosal epithelial cell line GES-1. Administration of
DGAT1
inhibitor effectively suppressed functional factors expression and induced cell death in MKN45.
Conclusion
The findings of this research provide an in-depth insight into the potential role and influences involved in
DGAT1
in the gastric cancer patients. And higher expression of
DGAT1
leads to lower overall survival (OS) rate in patients with poorly differentiated gastric cancer. Our findings suggest a potential role for
DGAT1
in the gastric cancer progression and inhibiting
DGAT1
might be a promising strategy in gastric cancer treatment.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Diacylglycerol O-Acyltransferase - antagonists & inhibitors
/ Diacylglycerol O-Acyltransferase - genetics
/ Diacylglycerol O-Acyltransferase - physiology
/ Diacylglycerol-acyltransferase 1
/ Gene Expression Regulation, Neoplastic
/ Genomics
/ Health Promotion and Disease Prevention
/ Humans
/ Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology
/ Mucosa
/ NADPH Oxidase 2 - physiology
/ Oncology
/ Ovaries
/ Sodium
/ Stomach Neoplasms - mortality
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