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Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

by Fu, Yun-Xing , Ji, Jing , Hu, Rong , Li, Jialing , Shan, Fang

in Adipocytes / Amenorrhea / Angiogenesis / Apoptosis / Autoimmunity / Biomedical and Life Sciences / Biomedical Engineering and Bioengineering / Bone marrow / Cancer / Cardiomyocytes / Cell Biology / Chemotherapy / Cytokines / Donations / Epidermal growth factor / Estrogen / Estrogens / Female / Follicle-stimulating hormone / Gonadotropins / Hormone replacement therapy / Humans / Immunologic Factors / Infertility / Insulin-like growth factors / Kinases / Life Sciences / Mesenchymal Stem Cells / Ovarian cancer / Ovarian function / Pituitary (anterior) / Placenta / Premature ovarian failure / Primary Ovarian Insufficiency - therapy / Regenerative Medicine / Regenerative Medicine/Tissue Engineering / Reproductive status / Review / Stem Cells / Transplantation / Tumor necrosis factor-TNF / Vascular endothelial growth factor / Womens health

2021

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Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

by Fu, Yun-Xing , Ji, Jing , Hu, Rong , Li, Jialing , Shan, Fang

2021

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Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

by Fu, Yun-Xing , Ji, Jing , Hu, Rong , Li, Jialing , Shan, Fang

2021

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Journal Article

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

Fu, Yun-Xing,

Ji, Jing,

Hu, Rong,

Li, Jialing,

Shan, Fang

2021

Overview

Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human mesenchymal stem cell (hMSC) therapy brings new prospects for POF. This study aimed to describe the types of MSCs currently available for POF therapy, their biological characteristics, and their mechanism of action. It reviewed the latest findings on POF to provide the theoretical basis for further investigation and clinical therapy.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ Biomedical and Life Sciences

/ Biomedical Engineering and Bioengineering