Journal Article

Salivary cortisol and alpha-amylase as stress markers to evaluate an individualized music intervention for people with dementia: feasibility and pilot analyses

Sindermann, Cornelia, Hillebrand, Mareike Christina, Wuttke, Alexandra, Montag, Christian, Heinzelmann, Rebecca, Haas, Heidrun, Wilz, Gabriele

2024

Overview

Objectives We investigated salivary biomarkers of stress, more specifically, cortisol and alpha-amylase, to evaluate effects of individualized music listening (IML) in people with dementia. Method Participants were N  = 64 nursing home residents with dementia (mean age = 83.53 ± 7.71 years, 68.8% female). Participants were randomly assigned to either listening to their favorite music every other day for a period of six weeks (intervention), or standard care (control). Using the Saliva Children`s Swab (SCS), saliva was collected before, after, and 20 min after IML sessions at the beginning and end of the intervention period for the analysis of salivary alpha-amylase and cortisol. Results Using the SCS was feasible in people with dementia. Nevertheless, there was no effect of IML on salivary stress markers. Discussion Although using SCS was feasible, active patient engagement is required. Future studies need to corroborate findings in larger samples. Trial registration German Clinical Trials Register: DRKS00015641, ISRCTN registry: ISRCTN59052178.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Aged / Aged, 80 and over / alpha-Amylases - analysis / alpha-Amylases - metabolism / Amylases / ANS / Biomarkers / Biomarkers - metabolism / Biomedical and Life Sciences / Biomedicine / Care and treatment / Clinical trials / Cognitive ability / Cognitive impairment / Complications and side effects / Corticosteroids / Cortisol / Dementia / Dementia - metabolism / Dementia disorders / Feasibility Studies / Female / Health aspects / Hormones / HPA axis / Humans / Hydrocortisone / Hydrocortisone - analysis / Hydrocortisone - metabolism / Intervention / Life Sciences / Male / Management / Measurement / Medical research / Medicine, Experimental / Medicine/Public Health / Music therapy / Music Therapy - methods / Non-pharmacological intervention / Nursing home patients / Physiological aspects / Physiology / Pilot Projects / Psychobiology of stress / Research Note / Saliva / Saliva - chemistry / Saliva - metabolism / Salivary diagnostics / Stress (Psychology) / Stress, Psychological - metabolism / Stress, Psychological - therapy / α-Amylase