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Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats
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Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats
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Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats
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Journal Article
Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats
2016
Overview
We have investigated the feasibility of administration of testosterone undecanoate （TU）-Ioaded injectable in situ-forming implant （ISFI） for contraception in adult male Sprague-Dawley rats. Male rats were treated with vehicle, TU-Ioaded ISFIs （540, 270 and 135 mg TU kg-1） or TU injections （45 mg TU kg-1 every 30 days） for 120 days. Fertility tests served for determining infertility or restoration of fertility in treated rats. Serum testosterone concentration, epididymal sperm count, motility, morphology, and histology of the testis were monitored. The TU-Ioaded ISFIs increased serum testosterone levels in rats steadily without fluctuation over 3 months. One month after TU administration, the epididymal sperm count decreased significantly in all experimental groups. After 3 months, the animals treated with 270 and 135 mg kg-~ TU-Ioaded ISFIs were 100% infertile, and no implantation sites were produced in the mated females. However, some of males treated with 540 mg kg-~ ISFI or TU injections were still fertile but numbers of implantation sites were also significantly lower than control values. TU-Ioaded ISFI at an appropriate dose has potential as a long-acting male contraceptive drug that suppresses spermatogenesis consistently over a period of 3 months.
Publisher
Wolters Kluwer - Medknow Publications,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
Subject
/ Contraceptive Agents, Male - administration & dosage
/ Control
/ in situ -forming implants; male contraception; rats; spermatogenesis; testosterone undecanoate
/ Male
/ Methods
/ Original
/ Rats
/ Sperm Motility - drug effects
/ Spermatogenesis - drug effects
/ Testosterone - administration & dosage
/ Testosterone - analogs & derivatives
/ 十一酸睾酮
/ 原位形成
/ 可注射
/ 成年
/ 植入物
/ 精子发生
/ 负载
/ 雄性大鼠
