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Computer-based cognitive tests and cerebral pathology among Japanese older adults

by Shimada, Hiroyuki , Makino, Keitaro , Kato, Takashi , Ito, Kengo

in Accumulation / Accuracy / Adults / Age / Aged / Aged patients / Aging / Alzheimer Disease - psychology / Alzheimer's disease / Amyloid beta-Peptides / Analysis / Asymptomatic / Beta-amyloid / Biological markers / Biomarkers / Care and treatment / Cerebrospinal fluid / Clinical trials / Cognition / Cognitive ability / Cognitive appraisal / Cognitive Dysfunction - diagnostic imaging / Cognitive Dysfunction - psychology / Computers / Delayed / Delayed recall / Dementia / Diagnosis / East Asian People / Education / Executive Function / Geriatrics / Geriatrics/Gerontology / Gerontology / Humans / Medical screening / Medicine / Medicine & Public Health / Memory / Neurodegenerative diseases / Neuroimaging / Neuropsychological Tests / Older people / Pathology / PET imaging / Positron emission tomography / Positron emission tomography (PET) / Predictions / Predictor / Regression analysis / Rehabilitation / Screening / Technology application / Tests / Tomography / Word lists

2023

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Computer-based cognitive tests and cerebral pathology among Japanese older adults

by Shimada, Hiroyuki , Makino, Keitaro , Kato, Takashi , Ito, Kengo

2023

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Computer-based cognitive tests and cerebral pathology among Japanese older adults

by Shimada, Hiroyuki , Makino, Keitaro , Kato, Takashi , Ito, Kengo

2023

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Journal Article

Computer-based cognitive tests and cerebral pathology among Japanese older adults

Shimada, Hiroyuki,

Makino, Keitaro,

Kato, Takashi,

Ito, Kengo

2023

Overview

Background This study aimed to identify the appropriate computer-based cognitive tests and cut-off values for estimating amyloid burden in preclinical Alzheimer’s disease drug trials. Methods Data from 103 older individuals, who underwent 18 F-florbetapir positron emission tomography and cognitive testing, were analyzed. Cognitive tests evaluated word list memory (immediate recognition and delayed recall), attention (Trail Making Test-part A), executive function (Trail Making Test-Part B), and processing speed (Digit Symbol Substitution Test [DSST]). Results The Aβ burden was significantly associated with word list memory (odds ratio [OR] = 0.42, 95% confidence interval [CI], 0.19–0.91) and DSST (OR = 0.35; 95% CI, 0.14–0.85). Positive predictive value and number needed to screen at a cut-off of 1.5 SD were better for word list memory and DSST among predictive values. Conclusions The computer-based memory and processing speed tests have the potential to reduce failure rates while screening individuals with Aβ accumulation in community settings.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Accumulation

/ Accuracy

/ Adults

/ Age

/ Aged

/ Aged patients

/ Aging