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Renin-angiotensin system modulators and other risk factors in COVID-19 patients with hypertension: a Korean perspective
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Renin-angiotensin system modulators and other risk factors in COVID-19 patients with hypertension: a Korean perspective
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Journal Article
Renin-angiotensin system modulators and other risk factors in COVID-19 patients with hypertension: a Korean perspective
2021
Overview
Background
While hypertension is the most common comorbid condition in patients with coronavirus disease 2019 (COVID-19) in Korea, there is a lack of studies investigating risk factors in COVID-19 patients with hypertension in Korea. In this study, we aimed to examine the effects risk factors in hypertensive Korean COVID-19 patients.
Methods
We selected patients from the database of the project #OpenData4Covid19. This information was linked to their 3-year historical healthcare data. The severity of the disease was classified into five levels. We also clustered the levels into two grades.
Results
The risk factors associated with COVID-19 severity were old age, diabetes mellitus, cerebrovascular disease, chronic obstructive pulmonary disease (COPD), malignancy, and renal replacement therapy. The use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) both before and after a diagnosis of COVID-19 were not associated with COVID-19 severity. A multivariate analysis revealed that old age, male sex, diabetes mellitus, and renal replacement therapy were risk factors for severe COVID-19.
Conclusion
The results suggest that in hypertensive patients with COVID-19, older age, male sex, a diagnosis of diabetes mellitus, and renal replacement therapy were risk factors for a severe clinical course. In addition, the use of ARBs and ACEIs before or after COVID-19 infection did not affect a patient’s risk of contracting COVID-19 nor did it contribute to a worse prognosis for the disease. These results highlighted that precautions should be considered for hypertensive patients with those risk factors and do not support discontinuation of ARBs and ACEIs during COVID-19 pandemic.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Angiotensin converting enzyme inhibitor (ACEI)
/ Angiotensin Receptor Antagonists - adverse effects
/ Angiotensin Receptor Antagonists - therapeutic use
/ Angiotensin receptor blocker (ARB)
/ Angiotensin-converting enzyme inhibitors
/ Angiotensin-Converting Enzyme Inhibitors - adverse effects
/ Angiotensin-Converting Enzyme Inhibitors - therapeutic use
/ Chronic obstructive pulmonary disease
/ COVID-19
/ Diabetes Mellitus - pathology
/ Female
/ Humans
/ Hypertension - complications
/ Male
/ Medicine
/ Methods
/ Renin
/ Renin-Angiotensin System - drug effects
/ Republic of Korea - epidemiology
/ Sex
/ Therapy
