Journal Article

Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study

Xia, Qing-Song, Zhang, Ming-min, Gong, Jing, Liu, Wen-hua, Lu, Fu-er, Dong, Hui, Wang, Qi, Wang, Ding-kun, Tu, Sheng-hao, Zhao, Yan, Huang, Zhao-yi

2020

Overview

Background COVID-19 is highly contagious, and the crude mortality rate could reach 49% in critical patients. Inflammation concerns on disease progression. This study analyzed blood inflammation indicators among mild, severe and critical patients, helping to identify severe or critical patients early. Methods In this cross-sectional study, 100 patients were included and divided into mild, severe or critical groups according to disease condition. Correlation of peripheral blood inflammation-related indicators with disease criticality was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve. Results Significantly, disease severity was associated with age ( R  = -0.564, P  < 0.001), interleukin-2 receptor (IL2R) ( R  = -0.534, P  < 0.001), interleukin-6 (IL-6) ( R  = -0.535, P  < 0.001), interleukin-8 (IL-8) ( R  = -0.308, P  < 0.001), interleukin-10 (IL-10) ( R  = -0.422, P  < 0.001), tumor necrosis factor α (TNFα) ( R  = -0.322, P  < 0.001), C-reactive protein (CRP) ( R  = -0.604, P  < 0.001), ferroprotein ( R  = -0.508, P  < 0.001), procalcitonin ( R  = -0.650, P  < 0.001), white cell counts (WBC) ( R  = -0.54, P  < 0.001), lymphocyte counts (LC) ( R  = 0.56, P  < 0.001), neutrophil count (NC) ( R  = -0.585, P  < 0.001) and eosinophil counts (EC) ( R  = 0.299, P  < 0.001). With IL2R > 793.5 U/mL or CRP > 30.7 ng/mL, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Conclusions Inflammation is closely related to severity of COVID-19, and IL-6 and TNFα might be promising therapeutic targets.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Age / Aged / Area Under Curve / Biomarkers / Blood / Blood cell count / C-reactive protein / C-Reactive Protein - metabolism / Coronaviruses / Correlation analysis / COVID-19 / COVID-19 - diagnosis / COVID-19 - immunology / Cross-Sectional Studies / Cytokine / Cytokines / Disease severity / Female / Humans / Illnesses / Indicators / Infectious Diseases / Inflammation / Inflammation - complications / Inflammation - immunology / Interleukin 10 / Interleukin 2 / Interleukin 2 receptors / Interleukin 6 / Interleukin 8 / Interleukin-10 - blood / Interleukin-6 - blood / Interleukin-8 - blood / Interleukins / Internal Medicine / Laboratories / Leukocyte Count / Leukocytes (eosinophilic) / Lymphocyte Count / Lymphocytes / Male / Medical Microbiology / Medicine / Medicine & Public Health / Middle Aged / Normal distribution / Parasitology / Peripheral blood / Procalcitonin / Procalcitonin - blood / Prognosis / Research Article / Retrospective Studies / ROC Curve / Severe acute respiratory syndrome coronavirus 2 / Severity of Illness Index / Statistics / Therapeutic targets / Tropical Medicine / Tumor Necrosis Factor-alpha - blood / Tumor necrosis factor-α / Viral diseases