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Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum

by Kundaje, Anshul , Grossman, Arthur R. , Greenleaf, William J. , Marinov, Georgi K. , Trevino, Alexandro E. , Xiang, Tingting

in 45/23 / 45/91 / 631/208/177 / 631/208/212 / Agriculture / Animal Genetics and Genomics / Arrays / Biomedical and Life Sciences / Biomedicine / Cancer Research / Cell cycle / Chromatin / Chromosomes / Dinoflagellates / Dinoflagellida - genetics / Domains / Eukaryotes / Experiments / Gene Function / Gene regulation / Genes / Genetic aspects / Genetic research / Genetic transcription / Genome / Genomes / Histones / Human Genetics / Letter / Liquid crystals / Mammals / Metabolism / Microorganisms / Models, Genetic / Natural history / RNA polymerase / Structure / Supercoiling / Three dimensional analysis / Topology / Transcription / Transcription, Genetic

2021

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Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum

by Kundaje, Anshul , Grossman, Arthur R. , Greenleaf, William J. , Marinov, Georgi K. , Trevino, Alexandro E. , Xiang, Tingting

2021

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Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum

by Kundaje, Anshul , Grossman, Arthur R. , Greenleaf, William J. , Marinov, Georgi K. , Trevino, Alexandro E. , Xiang, Tingting

2021

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Journal Article

Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum

Kundaje, Anshul,

Grossman, Arthur R.,

Greenleaf, William J.,

Marinov, Georgi K.,

Trevino, Alexandro E.,

Xiang, Tingting

2021

Overview

Dinoflagellate chromosomes represent a unique evolutionary experiment, as they exist in a permanently condensed, liquid crystalline state; are not packaged by histones; and contain genes organized into tandem gene arrays, with minimal transcriptional regulation. We analyze the three-dimensional genome of Breviolum minutum , and find large topological domains (dinoflagellate topologically associating domains, which we term ‘dinoTADs’) without chromatin loops, which are demarcated by convergent gene array boundaries. Transcriptional inhibition disrupts dinoTADs, implicating transcription-induced supercoiling as the primary topological force in dinoflagellates. Analysis of the three-dimensional architecture of the dinoflagellate Breviolum minutum genome identifies large topological domains (dinoTADs) demarcated by convergent gene array boundaries. Transcriptional inhibition disrupts dinoTADs.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 45/91

/ Animal Genetics and Genomics

/ Arrays