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Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

by Qiu, Andong , Lee, Peter , Chen, Xia , Leete, Thomas , Rittenberg, Alexander , Mu, Weiyi , Al-Awqati, Qais , Schmidt-Ott, Kai M , Lin, Chyuan-Sheng , Kitajewski, Jan , Barasch, Jonathan , Werth, Max , Viltard, Melanie , Hinze, Christian , Sarkar, Abby , Shawber, Carrie J , Yu, Wenqiang , Paragas, Neal

in Adenosine triphosphatase / Animals / Body Patterning / Cell Biology / Cell interactions / Collecting duct / Developmental Biology and Stem Cells / Epithelial cells / Gene expression / Gene Expression Regulation, Developmental / Genetic aspects / Genomes / H+-transporting ATPase / Homeostasis / intercalated cells / Jag1 / Kidney / Kidney Tubules, Collecting - embryology / Kidneys / Mice / Notch protein / Pattern formation / Physiological aspects / principal cells / Repressor Proteins - metabolism / Rodents / Tfcp2l1 / Transcription factors / Transcription, Genetic

2017

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Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

2017

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2017

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Journal Article

Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

Qiu, Andong,

Lee, Peter,

Chen, Xia,

Leete, Thomas,

Rittenberg, Alexander,

Mu, Weiyi,

Al-Awqati, Qais,

Schmidt-Ott, Kai M,

Lin, Chyuan-Sheng,

Kitajewski, Jan,

Barasch, Jonathan,

Werth, Max,

Viltard, Melanie,

Hinze, Christian,

Sarkar, Abby,

Shawber, Carrie J,

Yu, Wenqiang,

Paragas, Neal

2017

Overview

Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor Tfcp2l1 coordinates IC and PC development. Tfcp2l1 induces the expression of IC specific genes, including specific H+-ATPase subunits and Jag1. Jag1 in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. Tfcp2l1 inactivation deletes ICs, whereas Jag1 inactivation results in the forfeiture of discrete IC and PC identities. Thus, Tfcp2l1 is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, Tfcp2l1 regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments.

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Publisher

eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd

Subject

Adenosine triphosphatase

/ Animals

/ Developmental Biology and Stem Cells