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Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History
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Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History
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Journal Article
Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History
2012
Overview
The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped ~2.3 million single-nucleotide polymorphisms in 220 southern Africans and found that the Khoe-San diverged from other populations ≥100,000 years ago, but population structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa; instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response; potential adaptive introgression of protection from ultraviolet light; and selection predating modern human diversification, involving skeletal and neurological development. These new findings illustrate the importance of African genomic diversity in understanding human evolutionary history.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
Subject
/ Adaptation, Biological - genetics
/ African Continental Ancestry Group
/ Animals
/ Biological and medical sciences
/ Blends
/ Botswana
/ Chromosomes, Human, Pair 10 - genetics
/ Chromosomes, Human, Pair 6 - genetics
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomes
/ Genomics
/ Globes
/ Human
/ Humans
/ Molecular and cellular biology
/ Muscle, Skeletal - physiology
/ Online
/ Polymorphism, Single Nucleotide
