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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
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Journal Article
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
2011
Overview
CD4⁺ T regulatory cells (Tregs), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, Tregs were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota, particularly clusters IV and XIVa of the genus Clostridium, promoted Treg cell accumulation. Colonization of mice by a defined mix of Clostridium strains provided an environment rich in transforming growth factor-β and affected Foxp3⁺ Treg number and function in the colon. Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Autoimmunity (experimental aspects and models)
/ Bacteria
/ Biological and medical sciences
/ Clostridium - growth & development
/ colitis
/ Colitis - prevention & control
/ colon
/ Forkhead Transcription Factors - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Immunoglobulin E - biosynthesis
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - metabolism
/ Intestine, Small - immunology
/ Mice
/ mucosa
/ rearing
/ Receptors, Pattern Recognition - physiology
/ Rodents
/ Specific Pathogen-Free Organisms
/ T-Lymphocytes, Helper-Inducer - immunology
/ T-Lymphocytes, Regulatory - immunology
