Journal Article

Genomic, transcriptomic and epigenomic sequencing data of the B-cell leukemia cell line REH

Erlandsson, Rikard, Övernäs, Elin, Hellstedt Kerje, Susanne, Ameur, Adam, Wiman, Ann-Christin, Marincevic-Zuniga, Yanara, Lagensjö, Johanna, Gezelius, Henrik, Feuk, Lars, Liljedahl, Ulrika, Raine, Amanda, Mosbech, Mai-Britt, Larsson, Pontus, Ekberg, Sara, Petri, Anna, Ramsell, Jon, Bunikis, Ignas, Nordlund, Jessica, Martin, Tom, Häggqvist, Susana, Lysenkova Wiklander, Mariya

2023

Overview

Objectives The aim of this data paper is to describe a collection of 33 genomic, transcriptomic and epigenomic sequencing datasets of the B-cell acute lymphoblastic leukemia (ALL) cell line REH. REH is one of the most frequently used cell lines for functional studies of pediatric ALL, and these data provide a multi-faceted characterization of its molecular features. The datasets described herein, generated with short- and long-read sequencing technologies, can both provide insights into the complex aberrant karyotype of REH, and be used as reference datasets for sequencing data quality assessment or for methods development. Data description This paper describes 33 datasets corresponding to 867 gigabases of raw sequencing data generated from the REH cell line. These datasets include five different approaches for whole genome sequencing (WGS) on four sequencing platforms, two RNA sequencing (RNA-seq) techniques on two different sequencing platforms, DNA methylation sequencing, and single-cell ATAC-sequencing.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acute lymphoblastic leukemia / Acute lymphocytic leukemia / Advancing Methods in Molecular Biology and Genetics / Analysis / Archives & records / Biology / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer research / Cell Line / Cell Line, Tumor / Child / Chromosomes / Data Note / Data Notes / Datasets / DNA methylation / DNA sequencing / Epigenomics - methods / Genetic aspects / Genomes / Genomics / Humans / Information management / Karyotypes / Leukemia / Leukemia, B-Cell - genetics / Leukemia, Lymphocytic, Chronic, B-Cell - genetics / Life Sciences / Long-read / Lymphatic leukemia / Lymphocytes B / Lymphocytic leukemia / Medical research / Medicine/Public Health / Methods / Methylation / Multi-omics / Next-generation sequencing / Nucleotide sequencing / Pediatrics / Quality control / Risk factors / RNA / RNA sequencing / Short-read / Transcriptome / Transcriptomics / Whole genome sequencing