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Investigating human-derived lactic acid bacteria for alcohol resistance
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Journal Article
Investigating human-derived lactic acid bacteria for alcohol resistance
2024
Overview
Background
Excessive alcohol consumption has been consistently linked to serious adverse health effects, particularly affecting the liver. One natural defense against the detrimental impacts of alcohol is provided by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), which detoxify harmful alcohol metabolites. Recent studies have shown that certain probiotic strains, notably
Lactobacillus
spp., possess alcohol resistance and can produce these critical enzymes. Incorporating these probiotics into alcoholic beverages represents a pioneering approach that can potentially mitigate the negative health effects of alcohol while meeting evolving consumer preferences for functional and health-centric products.
Results
Five lactic acid bacteria (LAB) isolates were identified:
Lactobacillus paracasei
Alc1,
Lacticaseibacillus rhamnosus
AA,
Pediococcus acidilactici
Alc3,
Lactobacillus paracasei
Alc4, and
Pediococcus acidilactici
Alc5. Assessment of their alcohol tolerance, safety, adhesion ability, and immunomodulatory effects identified
L. rhamnosus
AA as the most promising alcohol-tolerant probiotic strain. This strain also showed high production of ADH and ALDH. Whole genome sequencing analysis revealed that the
L. rhamnosus
AA genome contained both the
adh
(encoding for ADH) and the
adhE
(encoding for ALDH) genes.
Conclusions
L. rhamnosus
AA, a novel probiotic candidate, showed notable alcohol resistance and the capability to produce enzymes essential for alcohol metabolism. This strain is a highly promising candidate for integration into commercial alcoholic beverages upon completion of comprehensive safety and functionality evaluations.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Alcohol Dehydrogenase - genetics
/ Alcohol Dehydrogenase - metabolism
/ Aldehyde Oxidoreductases - genetics
/ Aldehyde Oxidoreductases - metabolism
/ Analysis
/ Chemistry and Materials Science
/ Drug resistance in microorganisms
/ Humans
/ Lacticaseibacillus rhamnosus - genetics
/ Lacticaseibacillus rhamnosus - metabolism
/ Lactobacillales - metabolism
/ Microbial Genetics and Genomics
