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A deeper insight into the sialome of male and female Culex quinquefasciatus mosquitoes
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A deeper insight into the sialome of male and female Culex quinquefasciatus mosquitoes
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Journal Article
A deeper insight into the sialome of male and female Culex quinquefasciatus mosquitoes
2023
Overview
Introduction
During evolution, blood-feeding arthropods developed a complex salivary mixture that can interfere with host haemostatic and immune response, favoring blood acquisition and pathogen transmission. Therefore, a survey of the salivary gland contents can lead to the identification of molecules with potent pharmacological activity in addition to increase our understanding of the molecular mechanisms underlying the hematophagic behaviour of arthropods. The southern house mosquito,
Culex quinquefasciatus
, is a vector of several pathogenic agents, including viruses and filarial parasites that can affect humans and wild animals.
Results
Previously, a Sanger-based transcriptome of the salivary glands (sialome) of adult C. quinquefasciatus females was published based on the sequencing of 503 clones organized into 281 clusters. Here, we revisited the southern mosquito sialome using an Illumina-based RNA-sequencing approach of both male and female salivary glands. Our analysis resulted in the identification of 7,539 coding DNA sequences (CDS) that were functionally annotated into 25 classes, in addition to 159 long non-coding RNA (LncRNA). Additionally, comparison of male and female libraries allowed the identification of female-enriched transcripts that are potentially related to blood acquisition and/or pathogen transmission.
Conclusion
Together, these findings represent an extended reference for the identification and characterization of the proteins containing relevant pharmacological activity in the salivary glands of
C. quinquefasciatus
mosquitoes.
Publisher
BioMed Central,BioMed Central Ltd,BMC
