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Low Programmed Cell Death 5 Expression is a Prognostic Factor in Ovarian Cancer
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Low Programmed Cell Death 5 Expression is a Prognostic Factor in Ovarian Cancer
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Journal Article
Low Programmed Cell Death 5 Expression is a Prognostic Factor in Ovarian Cancer
2015
Overview
Background: Ovarian cancer is a leading gynecological malignancy. We investigated the prognostic value of programmed cell death 5 (PDCD5) in patients with ovarian cancer.
Methods: Expression levels of PDCD5 mRNA and protein were examined in six ovarian cancer cell lines (SKOV3, CAOV3, ES2, OV1, 3AO, and HOC1A) and one normal ovarian epithelial cell line (T29) using reverse transcription polymerase chain reaction, Western blotting, and flow cytometry. After inducing PDCD5 induction in SKOV3 cells or treating this cell line with taxol or doxorubicin (either alone or combined), apoptosis was measured by Annexin V-FITC/propidium iodide staining. Correlations between PDCD5 protein expression and pathological features, histological grade, FIGO stage, effective cytoreductive surgery, and serum cancer antigen-125 values were evaluated in patients with ovarian cancer.
Results: PDCD5 mRNA and protein expression were downregulated in ovarian cancer cells. Recombinant human PDCD5 increased doxorubicin-induced apoptosis in SKOV3 cells (15.96 ± 2.07%, vs. 3.17 ± 1.45% in controls). In patients with ovarian cancer, PDCD5 expression was inversely correlated with FIGO stage, pathological grade, and patient survival (P < 0.05, R = 0.7139 for survival).
Conclusions: PDCD5 expression is negatively correlated with disease progression and stage in ovarian cancer. Therefore, measuring PDCD5 expression may be a good method of determining the prognosis of ovarian cancer patients.
Publisher
Medknow Publications Pvt Ltd,Medknow Publications and Media Pvt. Ltd,Lippincott Williams & Wilkins Ovid Technologies,Gynecology Oncology Center, Peking University People's Hospital, Beijing 100044, China%Center for Reproductive Medicine, Peking University People's Hospital, Beijing 100044, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer
Subject
/ Aged
/ Analysis
/ Apoptosis Regulatory Proteins - genetics
/ Apoptosis Regulatory Proteins - metabolism
/ Female
/ Humans
/ Leukemia
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - metabolism
/ Oncology
/ Original
/ Ovarian Cancer; Poor Prognosis; Programmed Cell Death 5
/ Ovarian Neoplasms - genetics
/ Ovarian Neoplasms - metabolism
/ Ovarian Neoplasms - pathology
/ Patients
/ Proteins
/ RNA
/ Surgery
/ Tumors
