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RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
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RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
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RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
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Journal Article
RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
2016
Overview
Development of alternatively activated （M2） macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors. Here, we report that RBP-J, a DNA-binding protein that integrates signals from multiple pathways including the Notch pathway, is critically involved in polarization of M2 macrophages. Mice deficient in RBP-J in the myeloid compartment exhibited impaired M2 phenotypes in vivo in a chitin-induced model of M2 polarization. Consistent with the in vivo findings, M2 polarization was partially compromised in vitro in Rbpj-deficient macrophages as demonstrated by reduced expression of a subset of M2 effector molecules including arginase 1. Functionally, myeloid Rbpj deficiency impaired M2 effector functions including recruitment of eosinophils and suppression of T cell proliferation. Collectively, we have identified RBP- Jas an essential regulator of differentiation and function of alternatively activated macrophages.
Publisher
Higher Education Press,Springer Nature B.V,Oxford University Press
Subject
/ arginase
/ Biomedical and Life Sciences
/ Cell Polarity - drug effects
/ Cell Proliferation - drug effects
/ Cell Proliferation - genetics
/ chitin
/ DNA结合蛋白
/ Gene Expression Regulation - drug effects
/ Gene Expression Regulation - immunology
/ Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics
/ Immunoglobulin J Recombination Signal Sequence-Binding Protein - immunology
/ Macrophage Activation - drug effects
/ Macrophage Activation - genetics
/ Mice
/ RBP-J
/ 介导
/ 嗜酸性粒细胞
/ 基因
/ 子集
/ 巨噬细胞
/ 极化响应
/ 甲壳素
