Asset Details
Do you wish to reserve the book?
Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE-/- mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE-/- mice
Do you wish to request the book?
Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE-/- mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE-/- mice
2021
Overview
Atherosclerotic plaques are characterized by an accumulation and subsequent oxidation of LDL, resulting in adaptive immune responses against formed or exposed neoepitopes of the LDL particle. Autoantibodies against native p210, the 3136–3155 amino acid sequence of the LDL protein apolipoprotein B-100 (apoB100) are common in humans and have been associated with less severe atherosclerosis and decreased risk for cardiovascular events in clinical studies. However, whether apoB100 native p210 autoantibodies play a functional role in atherosclerosis is not known. In the present study we immunized apoE
-/-
mice with p210-PADRE peptide to induce an antibody response against native p210. We also injected mice with murine monoclonal IgG against native p210. Control groups were immunized with PADRE peptide alone or with control murine monoclonal IgG. Immunization with p210-PADRE induced an IgG1 antibody response against p210 that was associated with reduced atherosclerotic plaque formation in the aorta and reduced MDA-LDL content in the lesions. Treatment with monoclonal p210 IgG produced a similar reduction in atherosclerosis as immunization with p210-PADRE. Our findings support an atheroprotective role of antibodies against the apoB100 native p210 and suggest that vaccines that induce the expression of native p210 IgG represent a potential therapeutic strategy for lowering cardiovascular risk.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/699
/ Aorta
/ epitope
/ Humanities and Social Sciences
/ Immunologi inom det medicinska området
/ Immunologi inom det medicinska området (Här ingår: Cell- och immunterapi)
/ Immunology in the Medical Area
/ Immunology in the Medical Area (including Cell and Immunotherapy)
/ Medicinska och farmaceutiska grundvetenskaper
/ Peptides
/ Plaques
/ Science
