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Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer
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Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer
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Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer
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Journal Article
Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer
2018
Overview
Background
The modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). The systemic inflammation score (SIS) has been shown to be more informative than the mGPS in CRC. The albumin-NLR, composed of albumin and the NLR, can also be a candidate for a valuable inflammation score. However, about the utility of the mGPS, SIS, and albumin-NLR for CRC patients who have received radical resections remains unclear.
Methods
This study enrolled 877 CRC patients, who underwent radical surgical resection between January 1, 2007 and December 31, 2014. The prognostic values of the mGPS, SIS, and albumin-NLR were compared by the Kaplan-Meier survival analysis, multivariate Cox regression modelling, and the time-dependent receiver operating characteristic curve analysis (ROC).
Results
In the Kaplan-Meier analysis, all three inflammation scores were significantly associated with overall survival (OS) in the group including all the patients (mGPS,
p
= 0.016; SIS,
p
< 0.001; albumin-NLR,
p
= 0.007) and in the left-sided colon tumour subgroup (mGPS,
p
= 0.029; SIS
p
= 0.0013; albumin-NLR,
p
= 0.001). In the right-sided colon tumour subgroup, only the albumin-NLR was associated with OS (
p
= 0.048). The albumin-NLR was the only independent prognostic factor of the three scores for OS in the multivariate survival analysis.
Conclusions
The albumin-NLR outperformed both the SIS and mGPS in predicting OS in CRC patients undergoing radical resection.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Albumin
/ Albumin-neutrophil-to-lymphocyte ratio
/ And intratumoural chronic inflammatory cell
/ Biomedical and Life Sciences
/ Colorectal Neoplasms - mortality
/ Colorectal Neoplasms - pathology
/ Colorectal Neoplasms - surgery
/ Female
/ Health Promotion and Disease Prevention
/ Humans
/ Male
/ Medical and radiation oncology
/ Methods
/ Modified-Glasgow prognostic score
/ Oncology
/ Outcome and process assessment (Medical care)
/ Patients
/ Tumors
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